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Crystal Structure of DOT1L in Complex with EPZ003696

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Protein Data Bank Japan2023-09-13 更新2026-03-21 收录
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Crystal Structure of DOT1L in Complex with EPZ003696 Descriptor: 5'-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(methyl)amino]-5'-deoxyadenosine, Histone-lysine N-methyltransferase, H3 lysine-79 specific Authors: Jin, L. Deposit date: 2012-04-09 Release date: 2012-10-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. Chem.Biol.Drug Des., 80, 2012
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2012-04-09
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