Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 20mGy/day gamma-rays for 400 days (Primary screening for 20mGyM familly).. Mus musculus

Transgenerational effects of continuous low dose-rate (LDR) gamma-ray irradiation have not been well studied. C57BL/6JNrs male mice were maintained in non-irradiated room for 400 days from 8 weeks of age. This study investigated the De novo mutation by comparing the parents and children. This is primary screening. This study was performed under contract with the Aomori Prefectural Government, Japan. Overall design: Two-condition experiment, C57 BL/6JNrs tail tissue non-irradiated male (20mGyMM), female (20mGyMF) and their progenies (20mGyM1 to 20mGyM8) vs. reference male mouse.