Liver transcriptional critical balance induced by acetaminophen is prevented by chronic copper loading

Using a Cebus capucinus model and after chronic copper oral administration, we assessed a global transcriptional liver adaptations induced by acutely challenging the animals with a unique high dose of oral acetaminophen (APAP). Capuchin monkeys fed daily 7.5 mg of Cu/kg for three years (chronic copper protocol) were challenged with a unique dose of 120 mg APAP /kg. Four-condition experiment, control vs. copper, control vs APAP, control vs copper + APAP. Biological replicates: 4 individual monkeys (two channel array, control vs treatmentcontrol). Two technical replicate per array.