Nitroalkanes as ketone synthetic equivalent in C-N and C-S bond formation reaction

The umpolung strategy has been explored with 2-nitropropane derivatives featuring stabilized carbanion to latent ketone equivalents. The consequence of changing intrinsic polarity at -carbon of nitroalkanes induces simultaneous installation of the C-N bond at geminal and C-S bond at vicinal positions of the nitro functionality. Although the vicinal position of nitroalkanes bears poor electronic bias, the latent ketone formation facilitates C-S bond formation in the dithiole-3-thione core structure. The application of this methodology is also demonstrated with the synthesis of amino derivatives of isothia-zole-3-thione., , # Nitroalkanes as ketone synthetic equivalent in C-N and C-S bond formation reaction

[Access this dataset on Dryad](https://doi.org/10.5061/dryad.612jm64gh)
DOI:10.5061/dryad.612jm64gh

FAIR Data is available as Supporting Information for Publication and includes the primary NMR FID files for compounds 6pb’, 3e”a, 3e”u, 3e”x, 3e”x, 3f”a, 3g”a, 3p’a, 3p’b, 3p’g, 3p’n, 3aa-3za, 3a’a-3e’a, 3en, 3pa-3pz, 3pa’, 4aqq, 4b’qq, 4m’qq, 4naq, 4paq, 4pgq, 4qaq, 4qqq, 4vqq, 4waq, 4yqq, 1a-1z, 1a’-1c’.

## Description of the data and file structure

The uploaded file contains folders and subfolders containing NMR data of synthesized molecules with code given to them in the article, which can be verified by opening the fid file using Mnova software. CIF file is also uploaded which contains the SC-XRD data.

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## Code/Software

Subscription based software were used to open and process raw data like

* Chemdraw to make structures.
* Mestrenova for processing NMR data.
*...,