p53- repressed miRNAs are involved with E2F in a feed forward loop promoting proliferation. Homo sapiens

There is a distinctive miRNA expression profile between early (young) and replicative senescence (old). We observed a cluster of miRNAs that were repressed upon senescence in both MRC-5 and WI-38 fibroblast cells. Overall design: miRNAs profiling in young and senescence human emryonic fibroblasts (MRC-5 and WI-38)