Mechanism of pharmacological activity of hydrogenated D2AAK1 derivatives

This study reports 14 novel D2AAK1 derivatives with enhanced properties as neuroprotective agents. These derivatives were tested for their inhibition effects on AChE and MAO-B, as well as their effect on cell viability under oxidative stress. D2AAK1 derivatives showed strong cytoprotective effects, increasing cell viability by up to 300%. These effects are linked to MAPK p38 and Nrf2 pathway interactions, known to promote antioxidant and anti-apoptotic responses. In vivo studies indicated a beneficial effect of the tested derivative on the memory processes in the novel object recognition test. These findings identify D2AAK1 derivatives as potential agents for the treatment of memory deficits.The following data are collected here:standard NMR data of the novel compounds,in vitro data regarding cell vitality after compound treatment,enzyme inhibition of the studied compounds (MAO-B and AChE),animal studies (the effect of a selected compound on memory processes),X-ray data of a selected compound.The main finding of the study is discovery of D2AAK1 analogs more potent than a parent compound.