Summary Statistics: Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases

Exome wide gene and single variant level summary statistics associated with the Nature Communications article "Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases". Gene Level Association Files gene_level_prostate_cancer_risk.txt: gene-level summary statistics for assocation with prostate cancer risk (case Vs controls) gene_level_prostate_cancer_severity.txt: gene-level summary statistics for assocation with prostate cancer severity (aggressive prostate cancer Vs non-aggressive prostate cancer) gene_level_prostate_cancer_agg_ctrl.txt: gene-level summary statistics for assocation of aggressive prostate cancer Vs controls Columns Gene Name Gene ENSG - Ensembl gene ID CA_model - collapsing analysis qualifying variant model (as in Supplementary Data 1 of article) CMH_P - meta analysis P-value CMH_OR - meta analysis odds ratio CMH_OR_LCI - meta analysis odds ratio lower confidence interval CMH_OR_UCI - meta analysis odds ratio upper confidence interval Total Qual Cases - number of cases carrying a qualifying variant Total Unqual Cases - number of cases not carrying a qualifying variant Total Qual Ctrls - number of controls carrying a qualifying variant Total Unqual Ctrls - number of controls not carrying a qualifying variant Single Variant level Association File single_variant_prostate_cancer_risk.txt - single variant level summary statistics for assocation with prostate cancer risk (case Vs controls) Columns chr - chromosome pos - genomic position effect_allele other_allele P - meta analysis P-value direction - direction of effect in individual cohorts (100KGP, MCPS, UKB_SAS, UKB_AFR, UKB_EUR, FinnGen).