Ir-Catalyzed Asymmetric Hydroarylation of Alkynes for the Synthesis of Axially Chiral Heterobiaryls

The catalytic hydroarylation of alkynes has emerged as
an excellent
methodology for the synthesis of functionalized alkenes with excellent
levels of regio- and stereocontrol (syn). However,
in spite of the great progress in this field, the number of asymmetric
methodologies is still scarce. Herein, we report an atroposelective
Ir-catalyzed C–H hydroarylation of alkynes, which enables the
asymmetric synthesis of axially chiral heterobiaryl trisubstituted
olefins in good to high yields and enantioselectivities up to 98%
ee.