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Synthesis of cyclopropyl-substituted furans by Brønsted acid promoted cascade reactions

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Mendeley Data2024-06-25 更新2024-06-27 收录
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Chloroacetic acid promotes an efficient and diastereoselective intramolecular cascade reaction of electron-deficient ynenones to deliver products featuring a 2,3,5-trisubstituted furan bearing a fused cyclopropyl substituent at the 5-position. Synthetically relevant polycyclic building blocks featuring rings of various sizes and heteroatoms have been synthesized in high yield using this mild acid-catalyzed reaction.

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2023-06-28
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