Room-Temperature CuI-Catalyzed Amination of Aryl Iodides and Aryl Bromides

A general
and effective CuI/N′,N′-diaryl-1H-pyrrole-2-carbohydrazide
catalyst system was developed for the amination of aryl iodides and
bromides at room temperature with good chemoselectivity between −OH
and −NH2 groups. Only 5 mol % of CuI and ligands
was needed in this protocol to effect the amination of various aryl
bromides and aryl iodides with a wide range of aliphatic and aryl
amines (1.3 equiv).