Welfare issues associated with the different treatment groups.

Numbers of animals experiencing various welfare problems, with "2/30" meaning that 2 out of a total of 30 animals were affected. Groups and treatment dosages are presented in Table 1. Wound dehiscence; incision wounds at the operation site. Self-mutilation-like behaviour; minor wounds, swelling or erosions on the paw affected by the neuropathic injury. Clinically affected; presence of clinical signs like depression, weight loss exceeding 5%, piloerection, crouched stance, ataxia, decreased food intake or less active appearance.