DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)

Dipeptidyl Peptidase IV (DPP4) cleaves 2 amino acids from the N-terminus of GLP-1, inactivating it. DPP4 determines the half life of GLP-1 in the bloodstream. It is unknown if the soluble form of DPP4, the membrane-bound form, or both catalyze the cleavage of GLP-1.

二肽基肽酶IV（DPP4）从GLP-1的N端切割两个氨基酸，从而使其失活。DPP4决定了GLP-1在血液中的半衰期。目前尚不清楚可溶性DPP4、膜结合性DPP4，抑或是两者共同催化了GLP-1的切割过程。