TP63/TP53 stimulates transcription of DDIT4 gene

Transcription of DDIT4 (REDD1) gene is stimulated by TP63, both during mouse embryonal development and under conditions of genotoxic and oxidative stress. TP53 stimulates DDIT4 transcription after TP53 activation by ionizing radiation, but it seems that TP63 is the main activator of DDIT4 transcription under stress conditions (Ellisen et al. 2002).

DDIT4（REDD1）基因的转录在啮鼠胚胎发育阶段以及遭受基因毒性及氧化应激条件下均受到TP63的激发。在TP53经电离辐射激活后，TP53能够促进DDIT4的转录，然而在应激条件下，TP63似乎成为了DDIT4转录的主要激活因子（Ellisen等，2002年）。