Studies on the mechanisms underlying Angiopoietin-like 4-induced epidermal stem cell proliferation

To elucidate the mechanism by which Angiopoietin-like 4 (Angptl4) exerts a pro-proliferative effect on epidermal stem cells (EpSCs), we conducted RNA-seq analysis of EpSCs derived from 8-week-old Angptl4 gene knockout (KO) mice and wild-type (WT) control mice to gain a global view of the transcriptome profile regulated by ANGPTL4. Overall design: Analysis of differentially expressed genes of EpSCs from Angptl4 KO and WT mice by RNA-seq.