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Effect of Morc1 knock out on gonocyte chromatin and transcriptome [RNA-Seq 2]

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To investigate the function of Morc1 to chromatin state during gonocyte stage when around 10,000 copies of transposons are deregulated. We performed ATAC-seq, RNA-seq, ChIP-seq (for H3K9me3) using gonocyte at four developmental timepoints (E13.5, E16.5, P0, P3) during gonocyte stage

为探究Morc1在生殖母细胞(gonocyte)阶段(该阶段约有10000个拷贝的转座子(transposons)出现表达失调)对染色质状态的调控作用,我们采集该阶段四个发育时间节点(E13.5、E16.5、P0、P3)的生殖母细胞样本,开展了ATAC-seq、RNA-seq以及针对组蛋白H3赖氨酸9三甲基化(H3K9me3)的ChIP-seq实验。

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