BindingDB Entry 50037770: Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure.

Small molecule binding data for protein 3-phosphoinositide dependent protein kinase-1, AKT/p21CIP1, AXL receptor tyrosine kinase, C-RAF, CaM kinase IV, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 4, Dual specificity mitogen-activated protein kinase kinase 6, Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7), Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Glycogen synthase kinase-3, Inhibitor of NF-kappa-B kinase (IKK), Insulin-like growth factor I receptor, MAP kinase ERK2, MAP kinase p38, MAP kinase-activated protein kinase 2, MAP kinase-activated protein kinase 5, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 13 (MAPK13), Mitogen-activated protein kinase 14, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase 9, PKC alpha and beta-2, Platelet-derived growth factor receptor, Platelet-derived growth factor receptor beta, Protein kinase C alpha type, Protein kinase C delta type, Protein kinase C iota (PKCι), Protein kinase C, epsilon, Protein kinase C, eta, Protein kinase C, gamma, Protein kinase N2, Rho-associated protein kinase, Ribosomal protein S6 kinase 2/S6K1, Ribosomal protein S6 kinase alpha 3, SRC, Serine/threonine-protein kinase AKT, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase CHK2, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase D1, Serine/threonine-protein kinase D2 (PKD2), Serine/threonine-protein kinase Sgk1, Tyrosine-protein kinase ABL, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BMX, Tyrosine-protein kinase Blk, Tyrosine-protein kinase CSK, Tyrosine-protein kinase SYK, Tyrosine-protein kinase ZAP-70, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), c-Jun N-terminal kinase, JNK, cAMP-dependent protein kinase (PKA), p21-Activated kinase 2 (PAK2), and p38 delta/gamma, Uniprot L7RSL3, O00141, O14733, O14757, O14920, O14965, O15111, O15264, O15530, O75116, O96017, P00519, P04049, P05129, P05771, P06493, P07948, P08069, P09619, P11362, P11802, P16234, P17252, P17612, P17948, P21802, P22607, P22612, P22694, P23443, P24723, P24941, P27361, P28482, P30530, P31749, P31751, P35968, P41240, P41743, P42684, P43403, P43405, P45983, P45984, P45985, P49137, P49841, P51451, P51812, P51813, P52564, P53778, P53779, Q00534, Q02156, Q02750, Q02763, Q05655, Q13177, Q15139, Q15759, Q16513, Q16539, Q16566, Q8IW41, Q9BZL6, Q9UBS0, and Q9Y243