Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment
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https://www.ncbi.nlm.nih.gov/sra/SRP195732
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资源简介：
This study demonstrates a specific cooperativity between perturbations in histone methylation and eroded telomeres to destabilize the differentiation of murine embryonic stem cells. Overall design: Murine embryonic stem cells of two different genotypes (WT or Tert-/-) were subjected to differentiation, and treated with compounds that modulated histone H3K27 tri-methylation to assess their impact upon the differentiation response
创建时间：
2020-05-13
