Aromatic C–H Bond Functionalized via Zwitterion Intermediates to Construct Bioxindole Containing Continuous Quaternary Carbons
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https://figshare.com/articles/dataset/Aromatic_C_H_Bond_Functionalized_via_Zwitterion_Intermediates_to_Construct_Bioxindole_Containing_Continuous_Quaternary_Carbons/10304750
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资源简介：
Both bioxindoles and continuous quaternary carbons play
important
roles in pharmaceutical scaffolds. However, few examples were developed
to construct bioxindoles containing continuous quaternary carbons
because of the steric hindrance effect. Here, a rhodium(II)-catalyzed
three-component reaction of N,N-disubstituted anilines,
3-diazooxindoles, and isatin ketimines to deliver the 3-amino-3′-aryl-bioxindole
compounds containing continuous quaternary carbons as products is
developed. This transformation is proposed to proceed in a Mannich-type
trapping of a zwitterion intermediate initiated from aromatic C–H
bond functionalization. Several of these compounds exhibit good inhibitory
activity against growth of osteosarcoma cell lines.
创建时间：
2019-10-30
