TODAY Genetics Study

The rise in childhood obesity has been accompanied by an increased prevalence of type 2 diabetes (T2D) mellitus in children and adolescents. Research has shown the importance of adequate treatment and management on the vascular disease progression of T2D in adults, but research on the treatment and clinical course of T2D in youth has been limited. The TODAY (Treatment Options for Type 2 Diabetes in Adolescents & Youth) study was a 3-arm, prospective, randomized, partially blinded clinical trial of treatment for adolescents diagnosed with T2D.

The TODAY Genetics study was an ancillary study of the TODAY interventional trial conducted under the auspices of the TODAY study group.

Individuals diagnosed with T2D before the age of 18 and had BMI ≥ 85th percentile were recruited from TODAY clinical centers and collaborators. Once enrolled, participants were asked to provide a one-time blood sample collection for analysis of diabetes type and DNA extraction. Information on participant and family medical history was also collected.

Note: Given that the TODAY Genetics study was an extension of the main TODAY study, any requestors interested in TODAY Genetics are strongly encouraged to review the TODAY study (https://repository.niddk.nih.gov/studies/today/).