Dengzhan Shengmai formulation ameliorates cognitive impairments

The mice were randomly divided into six groups (n =10): the normal (Nor), aging (Aging), melatonin (Mel), and DZSM (DZSM-L, DZSM-M, DZSM-H) groups. As shown in Figure 1A, the CI model was established by intraperitoneal injection of D-galactose (125 mg/kg/d) for 10 weeks. Mice in the Mel and DZSM groups (DZSM-L, DZSM-M, DZSM-H) received oral melatonin (100 mM/kg) or DZSM (0.054 g/kg/d, 0.162 g/kg/d, 0.486 g/kg/d), respectively, for 6 weeks, after 4 weeks of D-galactose induction.