Acetylcholine waves and dopamine release in the striatum

Striatal dopamine encodes reward, with recent work showing that dopamine release occurs in spatiotemporal waves. However, the mechanism of dopamine waves is unknown. Here we report that acetylcholine release in mouse striatum also exhibits wave activity, and that the spatial scale of striatal dopamine release is extended by nicotinic acetylcholine receptors. Based on these findings, and on our demonstration that single cholinergic interneurons can induce dopamine release, we hypothesized that the local reciprocal interaction between cholinergic interneurons and dopamine axons suffices to drive endogenous traveling waves. We show that the morphological and physiological properties of cholinergic interneuron – dopamine axon interactions can be modeled as a reaction-diffusion system that gives rise to traveling waves. Analytically-tractable versions of the model show that the structure and the nature of propagation of acetylcholine and dopamine traveling waves depend on their coupling, and..., , , # Raw data accompanying manuscript entitled \"Acetylcholine waves and dopamine release in the striatum\"

[https://doi.org/10.5061/dryad.b5mkkwhk8](https://doi.org/10.5061/dryad.b5mkkwhk8)

The dataset includes all the raw data belonging to Figures 1-3 in the main text and Supplementary Figs. 1-2.
These include movies of the Acetylcholine indicators in the dorsal striatum (Figure 1 & Supplementary Fig. 1), and the two-photon laser scanning microscopy in conjunction with electrophysiological data regarding dopamine and acetylcholine release in acute striatal slices (Figs 2-3 and Supplementary Fig. 2). Each dataset includes it's own README files.