Palladium-Catalyzed Amide-Directed Enantioselective Hydrocarbofunctionalization of Unactivated Alkenes Using a Chiral Monodentate Oxazoline Ligand

A Pd-catalyzed amide-directed
enantioselective hydrocarbofunctionalization
of unactivated alkenes with C–H nucleophiles has been developed
using a chiral monodentate oxazoline (MOXin) ligand. Various indoles
react at C3 position with aminoquinoline-coupled 3-alkenamides to
give γ addition products in good to excellent yield and enantioselectivity.
This study represents an important advance of the development of chiral
monodentate oxazoline ligands, which have been underexplored for asymmetric
catalysis.