Table1_Intakes of folate, vitamin B6, and vitamin B12 and cardiovascular disease risk: a national population-based cross-sectional study.docx

BackgroundOnly a few studies that investigated dietary intakes of folate, vitamin B6, and vitamin B12 in relation to cariovascular disease (CVD). This study aimed to assess the association of dietary folate, vitamin B6, and vitamin B12 with CVD in the United States population.MethodsA cross-sectional analysis of 65,322 adults aged ≥ 20 years who participated in the Third National Health and Nutrition Examination Survey (NHANES III) and NHANES 1999–2018. Before 2003, dietary intake data were assessed using a 24-hour dietary call, and two 24-hour dietary calls were used during 2003 and 2018. Odds ratios and 95% confidence intervals (CIs) for CVD associated with dietary folate, vitamin B6, and vitamin B12 were estimated using multivariate logistic regression models.ResultsDietary vitamin B6 intake were inversely associated with the odds of CVD. In males, the multivariable OR for the highest vs. lowest quartiles of vitamin B6 was 0.77 (95%CI: 0.61–0.97, Ptrend = 0.013) for the odds of CVD. In females, the adjusted OR for the highest quartile of vitamin B6 compared with the lowest quartile was 0.73 (95%CI: 0.56–0.95, Ptrend = 0.038) for the odds of CVD. No significant association was observed between dietary folate and vitamin B12 intakes and the odds of CVD.ConclusionsOur findings indicate that higher intake of dietary vitamin B6 may be associated with lower prevalence of CVD, suggesting that dietary vitamin B6 has major public health implications in the prevention of CVD in the United States population.

背景：关于叶酸、维生素B6和维生素B12的膳食摄入与心血管疾病（CVD）关系的调查研究为数不多。本研究旨在评估美国人群中膳食叶酸、维生素B6和维生素B12与CVD之间的关联。方法：对第三届全国健康与营养调查（NHANES III）及1999-2018年NHANES中的65,322名≥20岁成年人进行了横断面分析。在2003年之前，膳食摄入数据通过24小时膳食回顾法进行评估，而在2003年和2018年期间则使用了两次24小时膳食回顾。采用多因素逻辑回归模型估计了与膳食叶酸、维生素B6和维生素B12相关的CVD的几率比及其95%置信区间（CI）。结果：膳食维生素B6的摄入量与CVD的几率呈负相关。在男性中，维生素B6摄入量最高的四分位数与最低的四分位数相比的多变量OR值为0.77（95%CI：0.61-0.97，P趋势=0.013），对于CVD的几率而言。在女性中，与最低四分位数相比，维生素B6摄入量最高的四分位数调整后的OR值为0.73（95%CI：0.56-0.95，P趋势=0.038），对于CVD的几率而言。膳食叶酸和维生素B12的摄入量与CVD的几率之间未观察到显著关联。结论：我们的研究结果提示，膳食维生素B6的高摄入量可能与CVD的较低患病率相关，这表明膳食维生素B6在美国人群中预防CVD具有重大的公共卫生意义。