RNA Nanotherapeutics with Fibrosis Overexpression and Retention (FORT) for MASH Treatment
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we present a new approach to treat fibrotic diseases, termed “Fibrosis overexpression and retention (FORT)”. In this strategy, we design 1) retinoid-derivative lipid nanoparticle (LNP) to enable enhanced mRNA overexpression in fibrotic regions, and 2) mRNA modifications which facilitate anchoring of therapeutic proteins in ECM.
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2024-08-28
