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Synthesis of an Advanced Intermediate en Route to the Mitomycin Natural Products

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/Synthesis_of_an_Advanced_Intermediate_en_Route_to_the_Mitomycin_Natural_Products/3040216
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An advanced intermediate in our planned synthesis of mitomycin C has been acquired in nine steps from tert-butyl glyoxylate. The aziridinyl pyrrolidine and quinone subunits are coupled regioselectively to arrive at an enamine that is prepared for C10 homologation.
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2006-12-21
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