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Transcriptomic differences between deeply quiescent and activated adult NSCs

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE239594
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To identify pathways regulating NSC quiescence, with a possible link to quiescence depth, we used double transgenic Tg(her4:drfp);Tg(mcm5:gfp) fish and paradigms predicted to highlight deep vs shallower quiescence. In adult fish (3 month-post-fertilization -mpf-), we performed bulk RNA sequencing on FACS sorted RFPhigh,GFPneg qNSCs (expressing strongly her4, signing NSCs transcriptionally remote from activation), and activated NSCs. To investigate transcriptomic differences between adult deeply quiescent NSCs and activated NSCs, we performed bulk RNA Seq
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2024-03-25
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