Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

This dataset contains the numerical values underlying all main figures (Figs. 1–6) and supplementary figures in Copley et al., \"Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration,\" published in Science. Data encompass: (1) in vitro TDP-43 aggregation prevention turbidity and sedimentation assay values across wild-type and disease-linked TDP-43 variants with multiple short RNA chaperones, including derived IC50 values, and FUS condensation assay values (Figs. 1, 3, 4; figs. S1, S3, S11, S15–S17); (2) electrophoretic mobility shift assay (EMSA) quantification of RNA binding (Figs. 1, 3, 4; figs. S2, S4, S15, S18); (3) fluorescence-based Clip34 stem-loop remodeling assay values (Fig. 1; fig. S2); (4) hydrogen–deuterium exchange mass spectrometry (HX-MS) processed deuterium uptake values for TDP-43 and TDP-435FL in free and Clip34-bound states (Fig. 2; figs. S4–S10); (5) all-atom molecular dynamics simulation-derived values, including per-resi..., , # Data for: Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

## Description of the data and file structure

**General information**

* **Associated publication:** Copley et al., \"Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration,\" *Science* (2026).
* **File naming convention:** Files are named by figure panel (e.g., Fig_1D_WT_aggregation.csv). The prefix indicates the figure number and panel, followed by a brief description of the data contents.
* **File formats:** Data are provided as .csv files for all figures for broad accessibility. Depending on the figure, data are additionally provided as either .xlsx (Excel) or .pzfx (GraphPad Prism) files; the latter include graphs and statistical analyses.
* **Rows:** Unless otherwise noted, each row represents an independent experimental replicate.
* **Missing values:** Blank cells indicate that the measurement was not performed or the condition..., ,