Crystal structure of the catalytic domain of PDE10A complexed with 3-(1-phenyl-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one
收藏Protein Data Bank Japan2024-03-20 更新2026-03-21 收录
下载链接：
https://pdbj.org/mine/summary/3wyk
下载链接
链接失效反馈官方服务：
资源简介：
Crystal structure of the catalytic domain of PDE10A complexed with 3-(1-phenyl-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one Descriptor: 3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ... Authors: Oki, H, Hayano, Y. Deposit date: 2014-09-01 Release date: 2014-11-19 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. J.Med.Chem., 57, 2014
创建时间：
2014-09-01
