EPI-Clone dataset X.1 : Targeted DNAm+DNA+RNA-seq from CD34+ BM cells of a healthy donor

This is dataset supports parts of the EPI-Clone manuscript. Here, targeted single cell methylation profiling (scTAMseq) was combined with targeted RNA-seq from the same cells (SDR-seq) to profile CD34+ cells from bone marrow of a healthy 51-year old male individual.
Dataset is a seurat (v5) object with the following assays, reductions and metadata:
ASSAYS:

RNA: RNA expression data for 120 target genes
DNAm: DNA methylation data, containing binary observations (0: amplicon not observed, i.e. dropout or absence of DNA methylation, 1: amplicon observed, i.e. DNA methylation). See the paper on scTAMseq
DIMENSIONALITY REDUCTION
pca, dynapca: PCA performed on all methylome data, or on consensus dynamic CpGs only
umap, dynaumap: UMAP computed on all methylome data, or on consensus dynamic CpGs only
projected: Methylome data projected on the reference CD34+ UMAP coordinate (add DOI!)
rnapca: PCA performed on RNA data
rnaumap: PCA performed on RNA data
For strategies how to obtain dimensionality reduction that reflect clonal identity, please see the github page accompanying the manuscript.
METADATA
nFeature_RNA, nFeature_DNAm, nFeature_NonHhaI: Number of RNA , DNAm and genotypoing amplicons observed
projected.cluster: Cell type, according to DNA methylation based projection on the CD34+ reference
CellType_rna: Cell type annotation according to RNA expression
CountsChrY: Y chromosome read counts
EPIclone_id: Clone, according to EPI-clone algorithm