Comparison of mRNA profiles of AGO2 sufficent and deficient pancreatic tissue in the LSL KRASG12D mouse model of pancreatic cancer

Purpose: The goals of this study are to compare NGS-derived transcripts to compare the expression of transcripts between AGO2 sufficent PDAC tissue and AGO2 deficient senescent PanINs in the mouse model Methods: mRNA profiles of 500 day-old AGO2+/+;KRASG12D;p48Cre and AGO2fl/fl;KRASG12D;p48Cre pancreatic tissue were generated in duplicates Results: mRNA transcripts were further analyzed using GSEA tools for mouse transcript quantitation Overall design: Pancreatic tissue mRNA profiles of AGO2+/+;KRASG12D;p48Cre and AGO2fl/fl;KRASG12D;p48Cre mice at 500-day time point were generated by deep sequencing.