Weight and Quantified gait parameters in spastwt/wt, spastinN384K/wt, spastinN384K/N384K mice at 1 year old.

Values are shown for the left hind limb unless otherwise stated; very similar results were obtained for the right hind limb. p-values for the effect of gender and genotype were calculated using two-way ANOVA. To correct for multiple testing, the alpha value for significance was calculated by dividing 0.05 by 8, using a highly conservative assumption of 8 independent tests (many of the tests are in reality related), to give α = 0.00625. spastwt/wt n = 10 (4 male, 6 female), spastinN384K/wt n = 16 (7 male, 9 female), spastinN384K/N384K n = 10 (6 male, 4 female).