CADM1-overexpression ES-2 cells

CADM1, an immunoglobulin superfamily member, frequently inactivated but function as a tumor suppressor in many solid tumors. However, how CADM1 expression in ovarian cancer cells and the mechanisms of its tumor suppressor function is not fully understood. We created ovarian cancer ES-2 cell lines in which CADM1 was stably up-regulated. Genes differentially expressed in CADM1-overexpressing ES-2 cells. To uncover the upstream regulatory pathways of CADM1 as a tumor suppressor in ovarian cancer, we performed RNA microarray profiling on both CADM1-overexpressed group ES-2 cells and mock control group cells. Gene expression profiles were obtained by microarray analysis using Affymetrix GeneChip® PrimeView™ Human Gene Expression Array.