Photoactivatable senolysis with single-cell resolution reverses aging

Cellular senescence is a crucial biological process associated with pathologies of aging. The elimination of senescent cells (SnCs) for the purpose to extend healthy lifespan has been supported by emerging evidence, which causes the exploration of drug approaches to induce SnCs death (senolysis). The challenge then becomes how to achieve the precision, broad-spectrum and controllability of senolysis. To this end, we here propose an unprecedented integration strategy to design a senotherapeutic agent Examination of control group, doxo group and doxo-KSL0608-Se group in liver of mice by RNA-seq, in quadruplicate