Association of Combined Solute Index Quintiles and Outcomes among 394 Hemodialysis Participants of the CHOICE Study.

Abbreviations: HR, Hazard Ratio; CI, Confidence Interval.
Hazard ratio per 1 standard deviation increase in the combined solute index in the continuous analysis modeled using Cox proportional hazards regression.
Note: Mean (Standard Deviation) for combined solute index is 5.5 (2.4).
1 Model 1: Crude model without adjustment.
2 Model 2: Minimally adjusted: HR adjusted for demographics (age, sex and race).
3 Model 3: Fully adjusted: HR adjusted for demographics (age, sex and race), clinical characteristics [body mass index, residual kidney function (self-reported ability to produce >1 cup of urine daily), Index of Coexistent Disease (ICED) score, diabetes and cardiovascular disease] and laboratory tests (Kt/VUREA, albumin, phosphate and creatinine).
NOTE: Combined solute index is calculated as follows
1) Generate standardized value of each solute with a mean of 0 and standard deviation of 1.
2) For each standardized solute create deciles based on percentiles of the data (range 1–10)
3) Calculate the combined solute index by averaging the decile category for each participant
4) Generate quintiles of the combined solute index. The lowest quintile is the reference.
Association of Combined Solute Index Quintiles and Outcomes among 394 Hemodialysis Participants of the CHOICE Study.