Deciphering the in vitro interaction dynamics of synthetic mucosal-associated gut bacteria community

Maintaining the integrity of the mucus layer is essential for host health. Studies have implicated that reduced or abnormal mucus production may lead to intestinal inflammation. When dietary nutrients are abundant in the gut, mucin degradation by microbes decreases. However, when nutrient availability declines, microbes increasingly turn to mucin as an energy source. This shift in resource utilization can profoundly alter interaction networks within the gut microbiota. In this study, we aimed to comprehensively investigate the interactions between the community members in different condition. Use non-targeted metabolomics to analyze the relationship between microbial interactions and metabolites.