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Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child

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NIAID Data Ecosystem2026-05-10 收录
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Plasmodium falciparum pathology is driven by the accumulation of parasite-infected erythrocytes in blood capillaries. We demonstrate a novel approach to identify pathogen-specific human monoclonal antibodies directly from plasma, combining mass-spectrometry analysis of antigen-purified polyclonal plasma IgG with Ig transcript sequencing.

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2026-02-23
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