Ruminocococaceae _ UCG-013 promotes anti-obesity in mice

Complex gene-environment interactions are considered necessary in the development of obesity . The gut microbiota composition can determine the conversion efficiency of food energy . Here, we aimed to identify the effects of specific gut microbes on the phenotype of mice fed a high-fat diet (HFD). After eight weeks of HFD feeding, male C57BL/6J mice in the HFD group ranking in the upper and lower quartiles for body weight gain were considered obese prone (OP) and obese resistant(OR), respectively. 16S rRNA gene sequencing was used to determine the composition of the intestinal microbiota, and fecal transplantation (FMT) was conducted to determine whether the microbiota plays a causal role in phenotypic variation.