Effects of EZH2 ablation on promoter accessibility in mouse PDAC lines derived from KrasG12D/PEC/Ikka?PEC tumors

We analyzed chromatin accessibility genome wide in EZH2KO and control cells derived from PDAC tumors of KrasG12D/PEC-Ikka?PEC PDAC model mice to gain insight how the ablation of EZH2 affects the accessibility of genes involved in PDAC tumorigenesis. Overall design: ATAC-seq was performed in two established cell lines, EZH2KO-UN-KC-6141, and control-UN-KC-6141. UN-KC-6141 is a line derived from PDAC tumors from KrasG12D/PEC-Ikka?PEC mice.