Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin
收藏Protein Data Bank Japan2023-09-06 更新2026-03-21 收录
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Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin Descriptor: (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... Authors: Amzel, L.M, Vogelstein, B, Gabelli, S.B, Mandelker, D. Deposit date: 2009-05-15 Release date: 2009-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane. Proc.Natl.Acad.Sci.USA, 106, 2009
创建时间：
2009-05-15
