Expected Traveling Time of Different Means of Signaling. (Calculated for 40 µm synapse-to-nucleus distance, which correspond to ∼30* µm synapse-to-soma distance).

*The distance from the soma to the most proximal spine was reported to be 39.7±12.1 µm [9].**Average maximal speed of granules traveling along a dendrite is 0.034±0.025 µm/s [15].***Regenerative Calcium waves were ruled out as means for synapse-to-CREB signaling [1].****Electrotonic speed (θ) was calculated according to the parameters in Table 2 using the conventional definition given by the classic cable theory.