Gut microbiota and targeted metabolomics of short-chain fatty acid reveals Qing-Re-Zao-Shi-Jian-Pi prescription on glucose and lipid metabolism in type 2 diabetic mice

16S rDNA high throughput sequencing was performed to analyze the intestinal flora.Results:QRZSF group had a significant effect on intestinal flora profiling in T2D mice. Comparedwith the model group at the phylum level, the abundance of Proteobacteria, Chloroflexi, Fusobacteriota, Cyanobacteria were increased, while the abundance of Patescibacteria and Verrucomicrobiota were decreased in QRZSF group. At the genus level, the abundance of Anaerotignum, Akkermansia, Candidatus_Saccharimonas were decreased, while the abundance of Acetatifactor and Bacteroides were increased. The possible mechanism is related to adjusting the abundance of gut microbiota and increasing Bacteroides.