IL-15 transpresentation by ovarian cancer cells improves CD34+ progenitor-derived NK cell's anti-tumor functionality

The present Data Share Collection (DSC) contains the raw data used for the publication of the
"IL-15 transpresentation by ovarian cancer cells improves CD34+ progenitor-derived NK cell's anti-tumor functionality" with DOI 10.1080/2162402X.2025.2465010. Here, we aimed at tackling the poor expansion and improve the functionality of HSPC-NK cells by transfecting ovarian cancer cells with mRNA codifying for IL-15 transpresentation mechanism. This way, we can improve the therapeutic potential of our HSPC-NK cell product for clinical use.

The DSC is organized in different folders, each representing one main or supplementary figure.
Each figure folder further constains separate folders for each one of the subfigures (A, B, C, etc...)
In these subfigure folders, the seeker can find the raw data from each one of the donors/experients used,
which might be further stratified in different folders to improve the "Findability" and "Accesibility" of the data according to the FAIR principle.

Note, each HSPC-NK cell donor is coded with 2/4 digits. Therefore, all samples/conditions with the
same 2/4 digits correspond to the same donor.

Samples labelled as transIL15, 1:1, 1.1 or 1_1 all correspond to the transpresenting IL-15 condition (as generated
from the combination of both IL-15- and IL-15Ra-encoding mRNA at a 1:1 proportion).

Should questions arise from this published DSC, please contact the Collection Managers.