Synthesis of Quaternary 3,3-Disubstituted 2‑Oxindoles from 2‑Substituted Indole Using Selectfluor
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https://figshare.com/articles/dataset/Synthesis_of_Quaternary_3_3-Disubstituted_2_Oxindoles_from_2_Substituted_Indole_Using_Selectfluor/3435917
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A facile method to construct quaternary 3,3-disubstituted 2-oxindole from 2-substituted indole without a catalyst in mild conditions is developed. A mechanistic study suggests that an iminium-intermediate-triggered 1,2-rearrangement is involved, and a trace amount of water is required for subsequent oxidation.
创建时间:
2016-06-27



