Overview of the quantitative influx characteristics (± 65% confidence limits) of the five investigated CPPs based on linear and biphasic modeling of the multiple time regression analysis data.

Kin = Unidirectional influx rate.
Vi = Initial brain distribution volume.
V0 = Vascular brain distribution volume, experimentally determined as the brain distribution volume of radioiodinated BSA.
Vg = Tissue brain distribution volume.
K1 = Unidirectional clearance or slope of the initial phase of the brain influx curve.
K = Net clearance or slope of the plateau phase of the brain influx curve.
Overview of the quantitative influx characteristics (± 65% confidence limits) of the five investigated CPPs based on linear and biphasic modeling of the multiple time regression analysis data.