Linkage data obtained for four overlapping regions, between two different subgroups.

Calculated LOD scores were improved after combining the two respective subject groups. It further validates the original computed LOD scores and serves as a partial replication of our linkage results.1Previously reported linked region (see Table S1 in File S1 for references).aA positive LOD score of 2.94 was obtained when no stratification was applied to 392 families (i.e., ALL). The linkage results shown here for the SNP rs11658900 suggest that the subgroups G3 and G4 are the strongest contributors to the original LOD score in the unstratified cohort (ALL). Therefore, combining G3 and G4 data resulted in an improvement in the LOD score relative to ALL with fewer families (i.e., 249).