Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [HiChIP]

To model and characterize the chromatin regulatory landscape of the very first developmental cell fates, we made use of three previously derived and well-characterized Trophoblast Stem Cell (TSCs), Embryonic Stem Cell (ESC) and Extra Embryonic Stem Cell lines (XENs) We performed HiChIP to profile putative enhancer interactions in TSC, ESC, XEN and EPISC cells Overall design: Identification of Enhancer interactions and enhancer rewiring between different developmental stages