Furosemide Solvates: Can They Serve As Precursors to Different Polymorphs of Furosemide?
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资源简介：
In
the present work, four solvates of furosemide with tetrahydrofuran
S(THF), 1,4-dioxane S(DIOX), N,N-dimethylformamide S(DMF), and dimethylsulfoxide S(DMSO) were crystallized,
the crystal structures were solved for S(THF), S(DIOX), and S(DMF).
The existence of S(THF) and S(DMSO) was not reported before; for the
previously known S(DIOX) and S(DMF), the crystal structures remained
unsolved. The detailed structural analysis of furosemide containing
crystal structures showed that the molecule of furosemide has a high
conformational lability because of the rotations of the sulfamoyl
and furanylmethylamino fragments. Some of the furosemide conformations
were shown to be stabilized by the intramolecular N–H···Cl
hydrogen bond. Desolvation of the four solvates was studied by TG
and X-ray diffraction and was shown to give different products depending
on the precursor and particle size: the desolvation of powder of S(THF)
and the large crystals of S(THF), S(DIOX), and S(DMF) gives Form-III
of furosemide, whereas powders of S(DIOX), S(DMF), and S(DMSO) give
Form-I.
创建时间：
2016-02-18
