Evaluation of assisted reproductive technology treatment outcomes based on stimulation dosages and anti-mullerian hormone levels

Background: Serum concentrations of anti-mullerian hormone (AMH)
correlate with ovarian response during assisted reproductive (ART)
treatment cycles. This prospective study was attempted to evaluate the
selection of ovarian stimulation protocols based on serum AMH levels in
patients and its impact on the results of ART. Results According to the
AMH levels, majority of the patients were normal responders (52.4%)
followed by high responders (29.8%) and low responders (17.8%). The
average FSH, HMG per day and number of days HMG required was found to be
significant among the different responders. Further, retrieval rate and
blastulation rate was found to be significant among the different
responders. A positive correlation was found between AMH and number of
oocytes retrieved and number of oocytes successfully fertilized and it was
found to be significant. In addition, there was a significant inverse
relationship between AMH levels and age. Conclusion The study outcome
reveals that retrieval rate, maturation rate, fertilization rate, embryo
utilization rate and blasturation rate were higher among the high
responders as compared to low responders. Thus, proper increase in dosages
of ovarian stimulation protocol is required among the low responders to
achieve quality embryos.