List of Pol γ mutations analyzed in this study and summary of results.

aAll strains listed are isogenic in the E134 background (see Materials and Methods). bThe details of the human POLG mutations and the associated disease can be found at the Human DNA polymerase γ mutation data base (http://tools.niehs.nih.gov/polg/). Arg+, able to synthesize arginine; CdCl2, cadmium chloride; CI, confidence interval; Er, erythromycin; Exo−, exonuclease deficient; MELAS, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes; MMS, methyl methanesulfonate; PEO, progressive external ophthalmoplegia. List of Pol γ mutations analyzed in this study and summary of results.