General Approach to Amides through Decarboxylative Radical Cross-Coupling of Carboxylic Acids and Isocyanides

Herein, we report
a silver-catalyzed protocol for decarboxylative
cross-coupling between carboxylic acids and isocyanides, leading to
linear amide products through a free-radical mechanism. The disclosed
approach provides a general entry to a variety of decorated amides,
accommodating a diverse array of radical precursors, including aryl,
heteroaryl, alkynyl, alkenyl, and alkyl carboxylic acids. Notably,
the protocol proved to be efficient for decarboxylative late-stage
functionalization of several elaborate pharmaceuticals, demonstrating
its potential applications.